Atopic ermatitis(AD) is a dermatologic disease which is characterized by severe, pruritus, typical distribution of skin leision and chronic relapsing course of disease. Even though the treatment of AD includes antihistamines, local and systemic
steroid
therapy, and antibiotics therapy, anything of them is not a method of complete remission. Especially systemic steroid therapy shows excellent effect for pruritus and skin leision, but considerable side effects of steroid do not permit long-term
use.
Even though active reserches for the pathogenesis of the AD, there are no known clear mechanisms of AD. Only several immunologic abnormalities are known to be participated in the pathogenesis of AD.
To study the role of eosinophil and dysregulation of T cell in AD, we checked the serum concentration of ECP and sIL-2R and compared the severity of the skin leision of AD, ECP ands sIL-2R of before and after thymopentin treatment.
@ES The results are as follows:
@EN (1) The level of serum ECP was significantly higher in AD children compared to the normal control (60.2±70.8㎍/l vs. 5.4±4.5㎍/l) and there was significant correlation between serum ECP and the severity score of AD.
(2) The level of sIL-2R in AD children was no significant difference compared to the normal control group.
(3) Thymopentin treatment of AD children who did not respond to the conventional treatment decreased the severity score of atopic dermatitis and the serum concentrations of ECP and sIL-2R.
This result suggests the eosinophil plays a major role in the pathogenesis of AD and the serum ECP secreted from activated eosinophil is the important index of clinical severity of AD, and the thymopentin treatment can be considered to be a next
step of
the treatment of AD children who do not respond to the conventional treatment.
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